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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Kaempferol, Docetaxel
Phytochemical Name Kaempferol (PubChem CID: 5280863 )
Anticancer drug Name Docetaxel (PubChem CID: 148124 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 854
Pair Name Kaempferol, Docetaxel
Disease Info [ICD-11: 2C82] Prostate cancer Investigative
Biological Phenomena Induction-->Autophagy
Gene Regulation Up-regulation Expression BECN1 hsa8678
Up-regulation Expression GABPA hsa2551
Down-regulation Expression MAP1LC3A hsa84557
Up-regulation Expression MAP1LC3B hsa81631
Up-regulation Expression SQSTM1 hsa8878
In Vitro Model DU145 Prostate carcinoma Homo sapiens (Human) CVCL_0105
PC-3 Prostate carcinoma Homo sapiens (Human) CVCL_0035
In Vivo Model Mouse was subcutaneously inoculated with 5×10⁵ androgen-independent PC-3 human prostate cancer cells
Result The above cellular and animal data suggest that docetaxel in combination with kaempferol has significant anti-prostate cancer effects and that it works by inducing autophagy in cells.
03. Reference
No. Title Href
1 Combination of Kaempferol and Docetaxel Induces Autophagy in Prostate Cancer Cells In Vitro and In Vivo. Int J Mol Sci. 2023 Sep 25;24(19):14519. doi: 10.3390/ijms241914519. Click
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